Science & Technology

With an eye on innovation™

we deliver first-in-class solutions and technologies to provide a brighter future for those at risk of losing their sight. EyePoint specializes in the development of sustained-release drug delivery to treat debilitating diseases of the eye and other localized, chronic conditions.

Vorolanib

Vorolanib Brings a Potential New MOA to the Treatment of VEGF-Mediated Retinal Diseases by Inhibiting all Isoforms of VEGF and PDGF

  • Potent and selective pan–VEGF receptor inhibition
  • Composition of matter patent into 2037
  • Demonstrated neuroprotection in a validated retinal detachment animal model
  • Inhibits PDGF which may lead to antifibrotic benefit
  • Reduced off-target binding – does not inhibit TIE-2 at clinically relevant doses

SoC=standard of care; ANG=angiopoietin; PDGF(R)=platelet-derived growth factor (receptor); PLGF=placental growth factor; TIE-2=tyrosine-protein kinase receptor; VEGF(R)=vascular endothelial growth factor (receptor).

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EYP-1901 Mechanism of Action

Sustained Release, PAN-VEGF Inhibition in Wet AMD

DURASERT®

Safe, Sustained IVT Drug Delivery

  • Delivered via a standard in-office IVT injection
  • Continuous, stable release of drug
  • Zero-order kinetics

Durasert E™: bioerodible

  • Insert consists of drug embedded within a bioerodible matrix
  • Designed to deplete drug load before matrix fully erodes

Durasert®: non-erodible

Drug embedded within a bioerodible matrix covered with non-erodible polyimide shell:

  • YUTIQ® (Alimera)
  • ILUVIEN® (Alimera)
  • RETISERT® (B&L)
  • VITRASERT® (B&L)

VERISOME® TECHNOLOGY

Verisome® technology is a novel, sustained-delivery platform

Highlights:

  • Biodegradable liquid in aqueous sphere
  • Customizable duration from one week to several months

DEXYCU®

DEXYCU is approved for the treatment of inflammation following ocular surgery.

Partnerships and BD Initiatives

EyePoint technologies have broad applicability across many therapeutic areas. Our validated technologies can be utilized to deliver new drugs or to repurpose existing molecules in new applications. EyePoint seeks additional strategic partners to collaborate on the development of new sustained-release drug suspensions and inserts, to access complementary research, and to expand our product portfolio.